![]() ![]() 1993, the linkage between ApoE4 and Alzheimer's disease had just been reported, so I was excited to hear about Mary Jo's work in this new area. I first met Mary Jo at Harvard Medical School, where she gave a seminar about her work on ApoE. If you would like to celebrate her life with a memory, anecdote, photo, or story that captures the MJ you knew, please use the comment box below.-Tom Fagan Comments Over a 30-year career, LaDu nurtured numerous fruitful collaborations. ![]() Her EFAD transgenic mice, which express human ApoE isoforms in a 5xFAD mouse background, are widely used today ( Youmans et al. LaDu uncovered how these two proteins modulate other pathways, both physiological and pathological, helping identify and understand potential drug targets, including retinoid receptors, and modulators of ApoE lipidation ( Tai et al., 20 news). ![]() Her early work focused on the relationship between ApoE and amyloid, teasing out the effects of the different apolipoprotein isoforms ( LaDu et al., 1994 Jordan et al., 1998 Tai et al. LaDu, who worked at the University of Illinois, Chicago, when she passed, will be best remembered in the Alzheimer’s field for her studies on the roles of ApoE and sex in AD pathology. On May 8, scientists and friends gathered in person and online for a memorial service, many recounting her dedication to science and to her students. Mary Jo LaDu, or MJ, as she was affectionately known among her many close friends and colleagues, passed away on March 28 after a prolonged illness. ![]()
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